- Human pathology

Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(4;14)(p16;q32)


Friday 10 February 2006


- plasma cell leukemia
- multiple myeloma
- plasmacytoma
- lymphoma showing the immunophenotype of chronic lymphocytic leukemia (20620602)
- monoclonal gammopathy of unknown significance (MGUS)

Molecular biology

- FGFR3-IGH rearrangements


- Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia. Bacher U, Haferlach T, Schnittger S, Weiss T, Burkhard O, Bechtel B, Kern W, Haferlach C. Cancer Genet Cytogenet. 2010 Jul 15;200(2):170-4. PMID: 20620602

- The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. Blood. 2011 Jan 6;117(1):211-20. PMID: 20974671