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Tuesday 7 February 2006

myopericytomas; benign myopericytoma

Definition: Myopericytoma is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. Myopericytoma arises most commonly in the dermis or subcutaneous tissue of the extremities in adults.


- Myopericytoma : circumscribed multilayered growth of short spindle cells around ectatic vessels. SMA (+).

Myopericytoma (MPC) is a recently proposed term to describe a group of tumours that originate from perivascular myoid cells and show a range of histological growth patterns. Only a small number of series describing MPC have been reported. MPC is frequently misdiagnosed as a sarcoma.


- painful slowly growing nodule
- concentric perivascular arrangement of plump spindle shaped cells
- concentric pattern around blood vessels
- myoid-appearing spindle cells
- accentuation the vessel walls
- fascicles of spindle cells, embedded in a myxoid stroma, bulged into the lumina of lesional vessels, reminiscent of myofibroma/myofibromatosis


- intravascular myopericytoma (12358814)


- tumoral spindle cells positive for

Diiferential diagnosis

- infantile myofibroma (infantile myofibromatosis )
- infantile hemangipericytoma
- liposarcomas
- monophasic synovial sarcoma
- angiomatoid MFH
- fibroma
- perineurioma
- leiomyoma
- leiomyosarcoma
- giant cell tumor of tendon sheath
- reparative giant cell granuloma
- angioleiomyoma
- glomus tumor
- hemangiomas
- arteriovenous malformation (AVM)

Features MPC IMF
HPC-like vascular space ++ +
concentric perivascular proliferation +++ +
zonation/biphasic appearance + +++
glomus-like cells + to +++ -
hyalinized paucicellular areas + +++
myoid-like cells + ++
primitive cells + ++
intravascular bulging + ++
intravascular proliferation + ++
myoid nodules +/- ++
tumoral necrosis - +

From Dray et al., 2006 (16394283)

See also

- myopericytic tumors

  • malignant myopericytoma


- Wilson T, Hellquist HB, Ray S, Pickles J. Intranasal myopericytoma. A tumour with perivascular myoid differentiation: the changing nomenclature for haemangiopericytoma. J Laryngol Otol. 2007 Aug;121(8):786-9. PMID: 17419897

- Dray MS, McCarthy SW, Palmer AA, Bonar SF, Stalley PD, Marjoniemi V, Millar E, Scolyer RA. Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. J Clin Pathol. 2006 Jan;59(1):67-73. PMID: 16394283

- Gengler C, Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 2006 Jan;48(1):63-74. PMID: 16359538

- Mentzel T, Tos AP, Sapi Z, Kutzner H. Myopericytoma of Skin and Soft Tissues: Clinicopathologic and Immunohistochemical Study of 54 Cases. Am J Surg Pathol. 2006 Jan;30(1):104-113. PMID: 16330949

- McMenamin ME, Calonje E. Intravascular myopericytoma. J Cutan Pathol. 2002 Oct;29(9):557-61. PMID: 12358814