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MIM.186745 9p

Monday 6 February 2006

Cell-matrix adhesions involve transmembrane glycoproteins such as cell adhesion molecules (CAMs) and integrins (ITGs), which are thought to function via interactions of their cytoplasmic domains with proteins associated with the cytoskeleton, as vinculin (VCL) or talins (TLNs: TLN1 and TLN2).

TLN1 serves a function of linking vinculin (VCL) (MIM.193065) to the integrins (ITGs), and, thus, the cytoskeleton to extracellular matrix (ECM) receptors.

TLN1 has a mass of 270 kD and shares 23% N-terminal identity with ezrin (VIL2) (MIM.123900), which has similar functions.



See also

- cell-matrix adhesion
- cell adhesion molecules (CAMs)
- integrins (ITGs)