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SODs

Tuesday 23 September 2003

Superoxide dismutases (SODs) are found in many cell types and convert superoxide to H2O2 (2 O2- + 2 H → H2O2 + O2).

SODs group includes both manganese-superoxide dismutase, which is localized in mitochondria, and copper-zinc-superoxide dismutase, which is found in the cytosol.

Members

- SOD1 (cytosolic superoxide dismutase) (21q22.1)
- SOD2 (mitochondrial superoxide dismutase) (6q25.3)
- SOD3 (extracellular superoxide dismutase) (4pter-q21)

See also

- superoxide
- reactive oxygen species (ROS)
- oxydative stress

References

- Salvemini D, Cuzzocrea S: Superoxide, superoxide dismutase and ischemic injury. Curr Opin Investig Drugs 3:886, 2002.