Saturday 4 February 2006
Collagen fibril formation is associated with the oxidation of specific lysine and hydroxylysine residues by the extracellular enzyme lysyl oxidase.
This results in cross-linking between the chains of adjacent molecules, thus stabilizing the array that is characteristic of collagen (collagen cross-linking). Cross-linking is a major contributor to the tensile strength of collagen.
Vitamin C is required for the hydroxylation of procollagen, a requirement that explains the inadequate wound healing in scurvy.
cross-linking by transglutaminases (TGMs)
Pathology of TGMs
TGM1 and TGM5 germline mutations in genodermatoses
TGM2 auto-antibody in celiac disease
TGM3 auto-antibody in herpetifom dermatitis