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acute GVHD

Thursday 2 February 2006

Synopsis

- Rash develops 2-3 weeks after allogeneic transplant
- Characteristic histologic changes develop 3-6 weeks after transplant
- Primary targets

  • Skin 90% (cutaneous acute GVHD)
  • Liver 40-60% (hepatic acute GVHD)
  • GI tract 30-50% (digestive acute GVHD)

- Early recognition of GVHD and prompt intervention improves outcome
- Advanced GVHD easy to diagnose but mortality can be 50%
- Poor correlation between pathologic features and clinical definition of acute vs. chronic

See also

- graft-versus-host disease (GVHD)

  • acute GVHD
  • chronic GVHD