- Human pathology

Home > E. Pathology by systems > Nervous system > neurogenesis


Saturday 28 January 2006

During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length.

See also

- development
- neuroepithelial
- radial glial cells
- cell fate
- adult neurogenesis


- Jagasia R, Song H, Gage FH, Lie DC. New regulators in adult neurogenesis and their potential role for repair. Trends Mol Med. 2006 Sep;12(9):400-5. PMID: 16890023

- Guillemot F. Cellular and molecular control of neurogenesis in the mammalian telencephalon. Curr Opin Cell Biol. 2005 Dec;17(6):639-47. Epub 2005 Oct 13. PMID: 16226447

- Huttner WB, Kosodo Y. Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. Curr Opin Cell Biol. 2005 Dec;17(6):648-57. PMID: 16243506

- Gotz M, Huttner WB. The cell biology of neurogenesis. Nat Rev Mol Cell Biol. 2005 Oct;6(10):777-88. PMID: 16314867