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PGC1

Friday 27 January 2006

The transcriptional co-activator PGC1 (peroxisome proliferator-activated receptor co-activator 1) is a binding partner for NRF1.

Recent mammalian studies have identified PGC1 as a crucial regulator of cardiac mitochondrial number and function in response to energy demand. It has been proposed that PGC1 might regulate mitochondrial function in specialized cell types. Lehman et al. have suggested that the availability of PGC1 partners in a given tissue, such as NRF1 and PPAR (peroxisome proliferator-activated receptor), dictates the level of expression of enzymes and proteins in specific mitochondrial pathways..

Recent mammalian studies have identified PGC1 as a crucial regulator of cardiac mitochondrial number and function in response to energy demand.

It has been proposed that PGC1 might regulate mitochondrial function in specialized cell types. It has also been suggested that the availability of PGC1 partners in a given tissue, such as NRF1 and PPARs (peroxisome proliferator-activated receptors), dictates the level of expression of enzymes and proteins in specific mitochondrial pathways.