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MSI2

MIM.607897

Wednesday 25 January 2006

Musashi-2 (MSI2), like Musashi-1 (MSI1) (MIM.603328), is an RNA-binding protein. In mice, Msi1 and Msi2 are both expressed during development of the central nervous system (CNS).

Pathology

- HOXA9/MSI2 fusion gene in chronic myeloid leukemia by t(7;17)(p15;q23) with fusion of HOXA9 at 7p15 and MSI2 at 17q23

References

- Barbouti, A.; Hoglund, M.; Johansson, B.; Lassen, C.; Nilsson, P.-G.; Hagemeijer, A.; Mitelman, F.; Fioretos, T. : A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). Cancer Res. 63: 1202-1206, 2003. PubMed ID : #12649177#