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leukocyte migration

Wednesday 25 January 2006

The Src-family kinases (SFKs) Fgr and Hck inhibit chemokine signaling in polymorphonuclear leukocytes and dendritic cells by phosphorylation of PIR-B, an inhibitory receptor expressed on leukocytes.

In resting cells, PIR-B phosphorylation is constitutive but is decreased transiently by addition of chemokines. In Fgr/Hck-deficient cells, constitutive PIR-B phosphorylation is markedly decreased.

See also

- chemokine signaling
- cell migration
- cell invasion


- Brown EJ. Leukocyte migration: dismantling inhibition. Trends Cell Biol. 2005 Aug;15(8):393-5. PMID: 15982887