Wednesday 25 January 2006
The Src-family kinases (SFKs) Fgr and Hck inhibit chemokine signaling in polymorphonuclear leukocytes and dendritic cells by phosphorylation of PIR-B, an inhibitory receptor expressed on leukocytes.
In resting cells, PIR-B phosphorylation is constitutive but is decreased transiently by addition of chemokines. In Fgr/Hck-deficient cells, constitutive PIR-B phosphorylation is markedly decreased.
Brown EJ. Leukocyte migration: dismantling inhibition. Trends Cell Biol. 2005 Aug;15(8):393-5. PMID: #15982887#