Home > D. Systemic pathology > Immune system diseases > sarcoidosis

sarcoidosis

Monday 22 September 2003

Sarcoidosis is a granulomatous disorder of unknown etiology, associated with an accumulation of CD4+ T cells and a TH1 immune response.

WP

Links

- Sarcoidosis in The Yale Rosen Collection of Pulmonary Pathology on Flickr

Localization

- pulmonary sarcoidosis
- nodal sarcoidosis
- hepatic sarcoidosis
- salivary sarcoidosis

Types

- early-onset sarcoidosis
- induced by recombinant interferon-alpha (IFN-alpha) (IFN-associated sarcoidosis) (15958865)

Susceptibility loci

- truncating splice site mutation in BTNL2 gene (15735647)
- CARD15 mutations in early-onset sarcoidosis
- HLA-DRB1 locus (12934202)

References

- Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007 Nov 22;357(21):2153-65. PMID: 18032765