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17q21 region

Monday 23 January 2006

Pathology

- RARA rearrangements at 17q21

  • PML/RARA fusion gene by t(15;17)(q22;q21) in acute promyelocytic leukemia (APL) (PML at 15q22 and RARA at 17q21).
  • NUMA1/RARA fusion gene by t(11;17)(q13;q21) in acute promyelocytic leukemia (APL) (NUMA1 at 11q13 and RARA at 17q21).