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ECMO

Sunday 15 January 2006

Extracorporeal membrane oxygenation (ECMO) has become an established mode of therapy in many centers for potentially fatal neonatal respiratory failure refractory to conventional therapy.

Synopsis

- pulmonary interstitial hemorrhages
- pulmonary alveolar hemorrhages
- alveolar hyaline membranes
- reactive epithelial hyperplasia

  • bronchial
  • type II pneumocytes

- squamous metaplasia
- smooth muscle hyperplasia
- interstitial fibrosis
- replacement of the terminal airways and alveoli by tall columnar and mucin-producing epithelium

- pulmonary calcifications

  • alveolar calcifications
  • bronchiolar calcifications

References

- Chou P, Blei ED, Shen-Schwarz S, Gonzalez-Crussi F, Reynolds M. Pulmonary changes following extracorporeal membrane oxygenation: autopsy study of 23 cases. Hum Pathol. 1993 Apr;24(4):405-12. PMID: 8491481