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Home > A. Molecular pathology > introns


Saturday 14 January 2006

Eukaryotic genes are interrupted by spliceosomal introns, which are removed from gene transcripts.

The number of introns per gene varies by more than two orders of magnitude between species, implying that there has been extensive intron loss and/or gain throughout eukaryotic evolution.


- Irimia M, Penny D, Roy SW. Coevolution of genomic intron number and splice sites. Trends Genet. 2007 Apr 17; PMID: 17442445

- Roy SW, Gilbert W. The evolution of spliceosomal introns: patterns, puzzles and progress. Nat Rev Genet. 2006 Mar;7(3):211-21. PMID: 16485020

- Roy SW. Intron-rich ancestors. Trends Genet. 2006 Sep;22(9):468-71. PMID: 16857287

- Jeffares DC, Mourier T, Penny D. The biology of intron gain and loss. Trends Genet. 2006 Jan;22(1):16-22. PMID: 16290250