Monday 9 January 2006
Definition: BMP7 is a member of the BMPs protein family and of the transforming growth factor-beta superfamily.
BMP7 was shown to counteract transforming growth factor-beta-mediated fibrosis.
BMP7 was recently identified in our genomewide copy number and expression survey as being activated through amplification in breast cancer cell lines.
Bone morphogenetic proteins (BMPs) make up a family of extracellular signaling molecules that play a critical role in vertebrate development and both inhibit and stimulate growth in cancer cells.
BMP7 copy number increase (16%) (16419056)
- strongly elevated BMP7 protein expression by immunochemistry (71.4%) (16419056)
In gastric cancer, Bone morphogenetic protein-7 expression is significantly correlated with patient postoperative outcome, especially in the undifferentiated group. (21224856)
- Multivariate analysis reveals BMP-7 expression as one of the independent prognostic factors next to the depth of invasion and nodal involvement (P < 0.01).
- There is a possible regulation of gastric cancer progression by autocrine or paracrine BMP-7 loops. (21224856)
- BMP-7 expression can be used as one of the strong predictors of risk of tumour recurrence in gastric cancer. (21224856)
Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjarvi T, Kallioniemi A. Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer. 2006 Apr;45(4):411-9. PMID: 16419056
Expression of BMP-7 in human gastric cancer and its clinical significance. Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S. Br J Cancer. 2011 Jan 11. PMID: 21224856