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BMP7

MIM.112267 Chr.20

Monday 9 January 2006

Definition: BMP7 is a member of the BMPs protein family and of the transforming growth factor-beta superfamily.

BMP7 was shown to counteract transforming growth factor-beta-mediated fibrosis.

BMP7 was recently identified in our genomewide copy number and expression survey as being activated through amplification in breast cancer cell lines.

Bone morphogenetic proteins (BMPs) make up a family of extracellular signaling molecules that play a critical role in vertebrate development and both inhibit and stimulate growth in cancer cells.

Pathology

- BMP7 copy number increase (16%) (#16419056#)

- overexpression of the BMP7 protein (#16419056#)

  • strongly elevated BMP7 protein expression by immunochemistry (71.4%) (#16419056#)

- In gastric cancer, Bone morphogenetic protein-7 expression is significantly correlated with patient postoperative outcome, especially in the undifferentiated group. (#21224856#)

  • Multivariate analysis reveals BMP-7 expression as one of the independent prognostic factors next to the depth of invasion and nodal involvement (P<0.01).
  • There is a possible regulation of gastric cancer progression by autocrine or paracrine BMP-7 loops. (#21224856#)
  • BMP-7 expression can be used as one of the strong predictors of risk of tumour recurrence in gastric cancer. (#21224856#)

Reviews

- Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med. 2005 Nov;11(11):512-8. PMID: #16216558#

References

- Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjarvi T, Kallioniemi A. Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer. 2006 Apr;45(4):411-9. PMID: #16419056#

- Expression of BMP-7 in human gastric cancer and its clinical significance. Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S. Br J Cancer. 2011 Jan 11. PMID: #21224856#