Sunday 8 January 2006
Lipofuscin is the name given to brown pigment granules composed of lipid-containing residues of lysosomal digestion.
Lipofuscin pigment granules represent undigested material derived from intracellular lipid peroxidation.
It is considered one of the aging or "wear and tear" pigments. Lipofuscin deposits are found in the liver, kidney, heart muscle, adrenals, nerve cells, and ganglion cells. "Liver spots" commonly associated with aging are superficial dermal lipofuscin deposits. Some studies show lesser deposits of lipofuscin in calorie restricted diet.
Abnormal accumulation of lipofuscin is associated with a group of diseases of neurodegenerative disorder type called lipofuscinoses, e.g., neuronal ceroid lipofuscinosis, also known as Batten disease.
Terman A, Brunk UT. Lipofuscin. Int J Biochem Cell Biol. 2004 Aug;36(8):1400-4. PMID: 15147719