nodal necrosis / lymphoid necrosis
lymphatic sinus ectasia
vascular anomalies in the lymph node
pigments in the lymph node
nodal lymphoid hyperplasia / lymphocyte hyperplasia
nodal plasma cell hyperplasia
nodal macrophage hyperplasia
nodal extramedullary hematopoiesis (EMH)
Histopathology of the Lymph Nodes. Susan A. Elmor. 2006 (...)
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Angulated Giant Celsl with Clefting
Nodular Tenosynovitis (NTS) is a fairly common soft tissue lesion, often diagnosed as benign lesion clinically. Occasionally these, especially the recurrent lesions may mimic a malignant tumor, clinically and to a certain extent histologically.
Giant cells are sparse in some tumors. When present, they are not the classical osteoclastic type, having fewer nuclei (average: 13). They have a peculiar angulated rather than smooth rounded border (64% (...)
chondrosarcoma of skull base / skull base chondrosarcoma https://twitter.com/neuropathobern/status/855365569662644224
chordoma of skull base / clival chordoma / chordoma of the clivus
The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases.
Proteome integrity is maintained by the proteostasis network (PN), which consists of interconnected systems that regulate protein synthesis, folding, transport, and degradation in every cell.
The functionality of this network declines during aging, thus compounding the (...)
Verruca plana https://twitter.com/marammussab/status/854607545809346560
Genome-wide sequencing studies have shown that individual malignancies contain many mutations that range from those commonly found in tumor genomes to rare somatic variants present only in a small fraction of lesions.
Such rare somatic variants dominate the landscape of genomic mutations in cancer, yet efforts to correlate somatic mutations found in one or few individuals with functional roles have been largely unsuccessful.
Traditional methods for identifying somatic variants that drive (...)
protein interaction domains
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. 2017. doi:10.1371/journal.pcbi.1005428.
Retroelement-guided protein diversiﬁcation abounds in vast lineages of Bacteria and Archaea. 2017. http://www.nature.com/articles/nmicrobiol201745 http://www.nature.com/articles/nmicrobiol201745.epdf
Spontaneous: due to abscess , tuberculosis , emphysema , asthma
Traumatic: due to puncture of chest wall or lung
Therapeutic: formerly used to treat tuberculosis
Spontaneous idiopathic: young people, rupture of small, peripheral, apical subpleural bleb (s), usually subsides spontaneously, but may recur and be disabling primary spontaneous pneumothorax
Tension pneumothorax: acts as one-way valve to trap air during inhalation; may compress contralateral lung, (...)
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