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t(11;18)(q21;q21)

Friday 9 December 2005

BIRC3 at 11q21 and MALT1 at 18q21

Molecular biology

- BIRC3-MALT1 fusion transcript (API2-MALT1)

Tumors

- B-cell lymphomas

  • marginal zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALTs) (50%-60%)

References

- Wang G, Auerbach A, Wei M, Dow N, Barry TS, Hodge L, Schaffer D, Sobin LH, Aguilera NS. t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases. Mod Pathol. 2008 Sep 26. PMID: 18820661

- Suguro-Katayama M, Suzuki R, Kasugai Y, Nakamura T, Suzuki H, Hosokawa Y, Shiku H, Nakamura S, Seto M. Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma. Leukemia. 2003 Dec;17(12):2508-12. PMID: 14562112