Humpath.com - Human pathology

Home > D. General pathology > Blood and immunity > B-CLL

B-CLL

Wednesday 30 November 2005

B-cell chronic lymphocytic leukemia (B-CLL) is a heterogeneous malignant disease, both in terms of molecular abnormalities and clinical course.

Cytogenetics

- tumoral deletions

  • deletion 13q
  • deletion 11q
  • deletion 17p

- trisomy 12

- all of anomalies are of prognostic significance

See also

- cytogenetics

  • conventional cytogenetic analysis
  • fluorescence in situ hybridization (FISH)

See also

- chronic lymphocytic leukemia

References

- Novak U, Tobler A, Fey MF. Allelotyping in B-cell chronic lymphocytic leukemia (B-CLL). Leuk Lymphoma. 2004 May;45(5):887-96. PMID: 15291345