- Human pathology

Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral inversions > inv(16)(p13q22)


Friday 4 November 2005

Digital slides

- UI:1008 - Acute myeloid leukemia with inv(16) and increased abnormal eosinophils


- acute myeloid leukemia (acute myelogenous leukemia or AML) (5-10%)

  • M4-AML
    • M4eo-AML (M4-AML with marked eosinophilia) (all M4eo share 16q22 anomaly)
    • M4-AML without eosinophilia (20%)
  • M2-AML
  • M5-AML
  • frequent CNS involvement, according to some authors, in particular at relapse

- myelodysplastic syndromes (MDS)

Molecular biology

- CBFB/MYH11 fusion gene

See also

- 19q22
- t(16;16)(p13;q22)
- del(16)(q22)


- Rowe D, Strain L, Lowe C, Jones G. A case of acute myeloid leukemia with inv(16)(p13q22) reveals a novel MYH11 breakpoint and a new CBF beta-MYH11 transcript variant. Haematologica. 2007 Oct;92(10):1433-4. PMID: 18024381

- Sun X, Zhang W, Ramdas L, Stivers DN, Jones DM, Kantarjian HM, Estey EH, Vadhan-Raj S, Medeiros LJ, Bueso-Ramos CE. Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. Mod Pathol. 2007 Aug;20(8):811-20. PMID: 17571080

- Schnittger S, Bacher U, Haferlach C, Kern W, Haferlach T. Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patients. Leukemia. 2007 Apr;21(4):725-31. PMID: 17287858