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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > MLH1-associated pediatric cancer syndrome

MLH1-associated pediatric cancer syndrome

Monday 14 February 2011

See also

- MMR-associated pediatric cancer syndrome
- MMR genes
- MMR deficiency
- hereditary nonpolyposis colorectal cancer (HNPCCs)


- Homozygosity at variant MLH1 can lead to secondary mutation in NF1, neurofibromatosis type I and early onset leukemia. Alotaibi H, Ricciardone MD, Ozturk M. Mutat Res. 2008 Jan 1;637(1-2):209-14. PMID: 17889038

- Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation. Gallinger S, Aronson M, Shayan K, Ratcliffe EM, Gerstle JT, Parkin PC, Rothenmund H, Croitoru M, Baumann E, Durie PR, Weksberg R, Pollett A, Riddell RH, Ngan BY, Cutz E, Lagarde AE, Chan HS. Gastroenterology. 2004 Feb;126(2):576-85. PMID: 14762794