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MIM.134638 1q23

Wednesday 2 November 2005


- germline mutations in TNFSF6 in ALPS1B

  • Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder associated with defects in Fas-mediated apoptosis, characterized most often by childhood onset of lymphadenopathy, splenomegaly, hypergammaglobulinemia, and autoimmune phenomena.

- polymorphism in lung cancer susceptibility (15937082)

See also


  • mutations in TNFRSF6 gene encoding Fas (CD95/Apo-1)