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del(6q)

Wednesday 2 November 2005

Deletion of the long arm of chromosome 6 (del(6q)) is more frequently described in lymphoid proliferations than in other hematological malignancies.

Regions

- deletions are mainly reported to be terminal, but also interstitial (6q11-14)

Tumors

- acute lymphoblastic leukemia (ALL)

- chronic lymphocytic leukemia (CLL)

  • atypical chronic lymphocytic leukemia

- prolymphocytic leukemia
- multiple myeloma (15%)
- non-Hodgkin lymphomas (NHL) (15% cases)

  • Burkitt lymphoma

- high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma (16865685)

- various cancers

See also

- tumoral deletions

References

- Array comparative genomic hybridization reveals a very high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma. Bosga-Bouwer AG, Kok K, Booman M, Boven L, van der Vlies P, van den Berg A, van den Berg E, de Jong B, Poppema S, Kluin P. Genes Chromosomes Cancer. 2006 Oct;45(10):976-81. PMID: 16865685