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ICAM1

Tuesday 1 November 2005

ICAM-1 is a cell adhesion molecule that belongs to the Ig-superfamily, with a glycoprotein structure playing a key role in leukocyte recruitment into inflammatory sites, as well as in leukocyte activation and effector function.

Proteolytic cleavage of ICAM-1 results in the formation of a soluble form, sICAM-1, which is present in low-serum levels in healthy individuals but becomes elevated in inflammatory and malignant conditions.

The ICAM1 gene is located on chromosome 19 and contains two well-known single-nucleotide polymorphisms (SNP) of +241G/A (G241R) and +469A/G (K469E).

Pathology

- ICAM1 polymorphisms in susceptibility to cerebral malaria (as CD56).

See also

- CD56

References

- Benson V, McMahon AC, Lowe HC. ICAM-1 in acute myocardial infarction: a potential therapeutic target. Curr Mol Med. 2007 Mar;7(2):219-27. PMID: 17346172