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cervical squamous cell carcinoma

Monday 31 October 2005

Cancer of the uterine cervix is the second largest cause of cancer deaths in women. Cervical carcinomas develop as a result of multiple genetic alterations.

Allelotyping (LOH frequency > 25%) (9699535)

3p21 LOH
4p16 LOH 25%-92% 11006038
5p15 LOH
6p LOH
6q14 LOH
6q22 LOH
11q23 LOH
15q21 LOH
17p13 LOH
18q22-qter LOH
19q13 LOH
Xq LOH

Regional amplifications

- 3q24-28 amplification (90%)
- 8q24.3 amplification
- 11q22.2 amplification
- 20q13 amplification

DNA repair

- microsatellite instability (MSI): 7% (9699535)

Overexpressed genes (17243165)

EPHB2 (1p36), CDCA8 (1p34.3), AIM2 (1q22-23), RFC4, MUC4, and HRASLS (3q27-29), SKP2 (5p12-13), CENTD3 (5q31.3), PTK2, RECQL4 (8q24), MMP1 and MMP13 (11q22.2), AKT1 (14q32.3), ABCC3 (17q21-22), SMARCA4 (19p13.3) LIG1 (19q13.3), UBE2C (20q13.1), SMC1L1 (Xp11), KIF4A (Xq12), TMSNB (Xq22), and CSAG2 (Xq28)

Videos

- Cervical squamous cell carcinoma by Washington Deceit (1)

< object width="425" height="350"> < param name="movie" value="http://www.youtube.com/v/zB47nE-i8dQ"> < /param> < param name="wmode" value="transparent"> < /param> < embed src="http://www.youtube.com/v/zB47nE-i8dQ" type="application/x-shockwave-flash" wmode="transparent" width="425" height="350"> < /embed> < /object>

- Cervical squamous cell carcinoma by Washington Deceit (2)

< object width="425" height="350"> < param name="movie" value="http://www.youtube.com/v/J3kULzKGzws"> < /param> < param name="wmode" value="transparent"> < /param> < embed src="http://www.youtube.com/v/J3kULzKGzws" type="application/x-shockwave-flash" wmode="transparent" width="425" height="350"> < /embed> < /object>

References

- The natural history of cervical HPV infection: unresolved issues. Ciaran B. J. Woodman, Stuart I. Collins and Lawrence S. Young. Nature Reviews Cancer 7, 11-22 (January 2007)

- Narayan G, Bourdon V, Chaganti S, Arias-Pulido H, Nandula SV, Rao PH, Gissmann L, Durst M, Schneider A, Pothuri B, Mansukhani M, Basso K, Chaganti RS, Murty VV. Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes. Genes Chromosomes Cancer. 2007 Apr;46(4):373-84. PMID: 17243165

- Roden R, Wu TC. How will HPV vaccines affect cervical cancer? Nat Rev Cancer. 2006 Oct;6(10):753-63. PMID: 16990853

- Jones EE, Wells SI. Cervical cancer and human papillomaviruses: inactivation of retinoblastoma and other tumor suppressor pathways. Curr Mol Med. 2006 Nov;6(7):795-808. PMID: 17100604

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