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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral trisomies > trisomy 8

trisomy 8

Monday 31 October 2005

Trisomy 8 as the sole chromosomal aberration

- hematological proliferations

- extraskeletal mesenchymal chondrosarcoma (15899388)
- epithelioid smooth muscle tumor (1868039)
- pediatric undifferentiated soft tissue sarcomas (USTS) (17350464)
- chondroid cystic malformation of the lung with trisomy 8 mosaicism (18520437)
- ovarian Sertoli-Leydig cell tumor (11381376)

NB: Trisomy 8 in acute myeloid leukemia (AML). Trisomy 8 is the most frequently observed trisomy in acute myeloid leukemia (AML) occurring as a sole karyotype abnormality or in addition to other chromosome aberrations. Trisomy 8 in AML determines no specific disease characteristic but is a disease modulating secondary event.

Trisomy 8 with associated anomalies

- chronic myeloproliferative diseases (myeloid tumors) (but not found in essential thrombocythemia)

  • chronic myelogenous leukemia (CML)
  • polycytemia vera (PV)
  • idiopathic myelofibrosis

- myelodysplastic syndromes (MDS)

- acute leukemias

  • acute lymphocytic leukemia (ALL)
  • acute myeloid leukemias (AML)
    • acute monocytic leukemia (FAB M5b) with trisomy 8

- non-Hodgkin Lymphomas

  • Burkitt lymphoma

- chronic lymphocytic leukemia (17175382, 17074592, 18474297)

- chronic lymphoproliferative diseases

  • T-prolymphocytic leukaemia (exceptional)

- embryonal tumors

- soft tissue sarcomas

- mammary carcinomas

See also

- Oncobase

  • tumoral trisomies


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- Pozdnyakova O, Stachurski D, Hutchinson L, Ramakrishnan S, Miron PM. Trisomy 8 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 May;183(1):49-52. PMID: 18474297

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- Batanian JR, Bridge JA, Wickert R, Vogler C, Gadre B, Huang Y. EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). Cancer Genet Cytogenet. 2002 Feb;133(1):72-5. PMID: 11890993

- Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor. Manegold E, Tietze L, Günther K, Fleischer A, Amo-Takyi BK, Schröder W, Handt S. Hum Pathol. 2001 May;32(5):559-62. PMID: 11381376

- VanDevanter DR, George D, McNutt MA, Vogel A, Luthardt F. Trisomy 8 in primary esthesioneuroblastoma. Cancer Genet Cytogenet. 1991 Nov;57(1):133-6. PMID: 1756479