Home > G. Tumoral pathology > Cancer molecular profiling > Cancer cytogenetics > Tumoral trisomies > trisomy 8

trisomy 8

Monday 31 October 2005

Trisomy 8 as the sole chromosomal aberration

- hematological proliferations

- extraskeletal mesenchymal chondrosarcoma (15899388)
- epithelioid smooth muscle tumor (1868039)
- pediatric undifferentiated soft tissue sarcomas (USTS) (17350464)
- chondroid cystic malformation of the lung with trisomy 8 mosaicism (18520437)
- ovarian Sertoli-Leydig cell tumor (11381376)

NB: Trisomy 8 in acute myeloid leukemia (AML). Trisomy 8 is the most frequently observed trisomy in acute myeloid leukemia (AML) occurring as a sole karyotype abnormality or in addition to other chromosome aberrations. Trisomy 8 in AML determines no specific disease characteristic but is a disease modulating secondary event.

Trisomy 8 with associated anomalies

- chronic myeloproliferative diseases (myeloid tumors) (but not found in essential thrombocythemia)

  • chronic myelogenous leukemia (CML)
  • polycytemia vera (PV)
  • idiopathic myelofibrosis

- myelodysplastic syndromes (MDS)

- acute leukemias

  • acute lymphocytic leukemia (ALL)
  • acute myeloid leukemias (AML)
    • acute monocytic leukemia (FAB M5b) with trisomy 8

- non-Hodgkin Lymphomas

  • Burkitt lymphoma

- chronic lymphocytic leukemia (17175382, 17074592, 18474297)

- chronic lymphoproliferative diseases

  • T-prolymphocytic leukaemia (exceptional)

- embryonal tumors

- soft tissue sarcomas

- mammary carcinomas

See also

- Oncobase

  • tumoral trisomies

References

- Bouron-Dal Soglio D, Rougemont AL, De Buys Roessingh AS, Fetni R, Rypens F, Bouchard S, Montpetit A, Fournet JC. Chondroid cystic malformation of the lung with trisomy 8 mosaicism: a new cystic lung malformation. Am J Surg Pathol. 2008 Jul;32(7):1095-100. PMID: 18520437

- Pozdnyakova O, Stachurski D, Hutchinson L, Ramakrishnan S, Miron PM. Trisomy 8 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 May;183(1):49-52. PMID: 18474297

- Selvarajah S, Yoshimoto M, Prasad M, Shago M, Squire JA, Zielenska M, Somers GR.Characterization of trisomy 8 in pediatric undifferentiated sarcomas using advanced molecular cytogenetic techniques.Cancer Genet Cytogenet. 2007 Apr 1;174(1):35-41. PMID: 17350464

- Paulsson K, Johansson B. Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol (Paris). 2007 Feb;55(1):37-48. PMID: 16697122

- Schoch C, Kohlmann A, Dugas M, Kern W, Schnittger S, Haferlach T. Impact of trisomy 8 on expression of genes located on chromosome 8 in different AML subgroups. Genes Chromosomes Cancer. 2006 Dec;45(12):1164-8. PMID: 17001623

- Dodge W, Cruz J, Zamkoff K, Hurd D, Pettenati MJ. Use of fluorescence in situ hybridization to detect minimal residual disease in hematopoietic stem cell assays from peripheral blood stem cells of 2 patients with trisomy 8 acute myeloid leukemia. Stem Cells Dev. 2004 Feb;13(1):23-6. PMID: 15068690

- Batanian JR, Bridge JA, Wickert R, Vogler C, Gadre B, Huang Y. EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). Cancer Genet Cytogenet. 2002 Feb;133(1):72-5. PMID: 11890993

- Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor. Manegold E, Tietze L, Günther K, Fleischer A, Amo-Takyi BK, Schröder W, Handt S. Hum Pathol. 2001 May;32(5):559-62. PMID: 11381376

- VanDevanter DR, George D, McNutt MA, Vogel A, Luthardt F. Trisomy 8 in primary esthesioneuroblastoma. Cancer Genet Cytogenet. 1991 Nov;57(1):133-6. PMID: 1756479