Home > D. Systemic pathology > Hematopathology > cytotoxic T lymphocytes

cytotoxic T lymphocytes

Thursday 20 October 2005

Cytolytic lymphocytes (CTLs) are characterized by their inclusion of cytoplasmic granules containing effector molecules that can mediate target cell death. One mechanism of lymphocyte-mediated killing is the induction of target cell apoptosis. Central to this autolytic pathway is the activation of an endogenous endonuclease that degrades target cell DNA.

See also

- large granular lymphocytes
- TIA1
- granzyme-B (GZMB)


- T-cell mediated cytotoxicity


- Hong W. Cytotoxic T lymphocyte exocytosis: bring on the SNAREs! Trends Cell Biol. 2005 Dec;15(12):644-50. PMID: #16260137#