Home > D. Systemic pathology > Hematopathology > cytotoxic T lymphocytes

cytotoxic T lymphocytes

Thursday 20 October 2005

Cytolytic lymphocytes (CTLs) are characterized by their inclusion of cytoplasmic granules containing effector molecules that can mediate target cell death. One mechanism of lymphocyte-mediated killing is the induction of target cell apoptosis. Central to this autolytic pathway is the activation of an endogenous endonuclease that degrades target cell DNA.

See also

- large granular lymphocytes
- TIA1
- granzyme-B (GZMB)

Videos

- T-cell mediated cytotoxicity

< object width="425" height="350"> < param name="movie" value="http://www.youtube.com/v/9-C1VVpqsn8"> < /param> < param name="wmode" value="transparent"> < /param> < embed src="http://www.youtube.com/v/9-C1VVpqsn8" type="application/x-shockwave-flash" wmode="transparent" width="425" height="350"> < /embed> < /object>

References

- Hong W. Cytotoxic T lymphocyte exocytosis: bring on the SNAREs! Trends Cell Biol. 2005 Dec;15(12):644-50. PMID: 16260137