chronic active gastritis
Tuesday 18 October 2005
HPC:311 : Follicular gastritis and active chronic gastritis, non-atrophical, Helicobacter pylori-associated
Definition: Chronic active gastritis is the inflammation of the stomach characterized by the simultaneous presence of a mononuclear cell infiltrate and neutrophilic polymorphonuclear inflammation.
Because this term may convey an entity (like chronic active hepatitis) rather than a phase of a single disease, it is preferable to use the term active as a descriptor, as in the original Sydney System (e.g., chronic gastritis, active).
Sydney system of grading
|Chronic inﬂammation||Increased lymphocytes and plasma cells in the lamina propria||Mild, moderate, or severe increase in density|
|Activity||Neutrophilic inﬁltrates of the lamina propria, pits, or surface epithelium||Less than one third of pits and surface inﬁltrated = mild; one third to two thirds = moderate; more than two thirds = severe|
|Atrophy||Loss of specialized glands from either antrum or corpus||Mild, moderate, or severe loss|
|Intestinal metaplasia||Intestinal metaplasia of the epithelium||Less than one third of mucosa involved = mild; one third to two thirds = moderate; more than two thirds = severe|
|Helicobacter pylori||H. pylori density||Scattered organisms covering less than one third of the surface = mild colonization; large clusters or a continuous layer over two thirds of surface = severe; intermediate numbers = moderate colonization|
The mucous neck regions appear hyperchromatic and are inﬁltrated with acute inﬂammatory cells.
Helicobacter pylori infection (Helicobacter pylori gastritis)
Crohn gastritis (Crohn disease)
- CVID-associated gastritis
focal active gastritis