Home > D. General pathology > CD18 deficiency

CD18 deficiency

MIM.600065 21q22.3

Tuesday 18 October 2005

Autosomal recessive disorder - Leukocyte adhesion deficiency type 1.


- recurrent bacterial infections
- impaired pus formation
- impaired wound healing
- abnormal adhesion-dependent functions of granulocytes, monocytes, and lymphocytes
- infection of umbilical cord stump
- omphalitis
- gingivitis (periodontosis)


- systemic juvenile rheumatoid arthritis


- leukocyte cell adhesion molecule defect
- reduced neutrophil phagocytic and respiratory burst
- response to bacteria and yeast
- reduced adherance to various substances
- reduced migration into infection sites