Tuesday 11 October 2005
Definition: Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas of elderly patients and has a predilection for the limbs.
The term myxofibrosarcoma has been adopted for lesions formerly known as myxoid MFH. These lesions have been moved into the category of fibroblastic tumors.
Myxofibrosarcomas are a distinct and reproducible entity (quite separate from lesions formerly known as pleomorphic MFH), which represent the commonest type of soft tissue sarcoma in older adults.
Myxofibrosarcomas show a particular tendency to arise in subcutaneous tissue of the limbs and show a broad spectrum of morphological grade, but even the high-grade lesions, which may contain non-distinctive pleomorphic areas reminiscent of so-called MFH.
They have a metastatic rate of only approximately 35%, which is lower than most other types of pleomorphic sarcoma.
Highly complex karyotypes with extensive intratumoral heterogeneity have been reported. No consistent aberration.
Nascimento AF, Bertoni F, Fletcher CD. Epithelioid Variant of Myxofibrosarcoma: Expanding the Clinicomorphologic Spectrum of Myxofibrosarcoma in a Series of 17 Cases. Am J Surg Pathol. 2007 Jan;31(1):99-105. PMID: 17197925