Home > G. Tumoral pathology > myxofibrosarcoma

myxofibrosarcoma

Tuesday 11 October 2005

Digital slides

- JRC:71 : Soft tissue (shoulder): Low-grade myxofibrosarcoma.

Definition: Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas of elderly patients and has a predilection for the limbs.

The term myxofibrosarcoma has been adopted for lesions formerly known as myxoid MFH. These lesions have been moved into the category of fibroblastic tumors.

Myxofibrosarcomas are a distinct and reproducible entity (quite separate from lesions formerly known as pleomorphic MFH), which represent the commonest type of soft tissue sarcoma in older adults.

Myxofibrosarcomas show a particular tendency to arise in subcutaneous tissue of the limbs and show a broad spectrum of morphological grade, but even the high-grade lesions, which may contain non-distinctive pleomorphic areas reminiscent of so-called MFH.

They have a metastatic rate of only approximately 35%, which is lower than most other types of pleomorphic sarcoma.

Variants

- epithelioid variant of myxofibrosarcoma (17197925)
- low-grade myxofibrosarcoma

Cytogenetics

- Highly complex karyotypes with extensive intratumoral heterogeneity have been reported. No consistent aberration.

References

- Nascimento AF, Bertoni F, Fletcher CD. Epithelioid Variant of Myxofibrosarcoma: Expanding the Clinicomorphologic Spectrum of Myxofibrosarcoma in a Series of 17 Cases. Am J Surg Pathol. 2007 Jan;31(1):99-105. PMID: 17197925