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chondroid lipoma

Tuesday 11 October 2005

Definition: Chondroid lipoma occurs most often in the limbs as a subcutaneous lesion in adults and is characterized by an admixture of chondroblast-like cells, bland-looking lipoblasts and mature adipocytes in varying proportions.

Although these lesions may be mistaken for sarcoma by the unwary, they appear to be entirely benign with virtually no tendency for local recurrence.

Cytogenetics

- t(11;16)(q13;p12-13) (11q13 and 16p12-13)

See also

- adipocytic tumors
- chondrocytic tumors

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Open references

- C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA. Genes Chromosomes Cancer. 2010 Sep;49(9):810-8. doi : 10.1002/gcc.20788
PMID: 20607705 Free

Paywall references

- Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. Flucke U, Tops BB, de Saint Aubain Somerhausen N, Bras J, Creytens DH, K├╝sters B, Groenen PJ, Verdijk MA, Suurmeijer AJ, Mentzel T. Histopathology. 2013 May;62(6):925-30. doi : 10.1111/his.12100
PMID: 23672313

- The evolving classification of soft tissue tumours: an update based on the new WHO classification. Fletcher CD. Histopathology. 2006 Jan;48(1):3-12. PMID: 16359532