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ovarian tumors

Friday 25 July 2003

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Classification (WHO)

I - Ovarian epithelial tumors (Surface epithelial-stromal tumors )

  • endometrioid tumors
    • Benign (cystadenoma )
    • Borderline tumors (endometrioid borderline tumor )
    • Malignant (endometrioid adenocarcinoma )
  • squamous cell tumors
  • epithelial-stromal tumors (mixed epithelial tumors )
  • Undifferentiated / unclassified epithelial tumors
    • adenocarcinoma (NOS)
    • undifferentiated carcinoma

II - ovarian sex cord-stromal tumors

  • Sex cord-stromal tumors of mixed or unclassified cell types
    • Sex cord tumor with annular tubules
    • Gynandroblastoma
    • Sex cord-stromal tumor, unclassified, NOS
  • Steroid cell tumors
    • Stromal luteoma
    • Leydig cell tumor
      • Leydig cell tumor, Hilus cell tumor type
      • Leydig cell tumor, non-hilar type
      • Leydig cell tumor, NOS
    • Steroid (lipid) cell tumors NOS
      • Well differentiated
      • Malignant

III - Ovarian germ cell tumors

  • Teratoma :
    • Immature
    • Mature
      • Solid
      • Cystic (dermoid cyst )
      • Monodermal (e.g., struma ovarii , carcinoid )

IV. Miscellaneous tumors

Macroscopical appearance

- ovarian cystic tumors
- ovarian surface epithelial tumors

Microscopical appearance

- ovarian tumors with prominent spindle cells

Differential diagnosis

- ovarian tumor-like lesions

  • follicle cyst
  • corpus luteum cyst
  • ovarian remnant syndrome
  • polycystic ovarian disease (PCOD)
  • stroma hyperthecosis
  • ovarian stromal hyperplasia
  • ovarian massive edema
  • ovarian fibromatosis
  • hilus Leydig cell hyperplasia
  • ovarian simple cyst
  • ovarian idiopathic calcification
  • uterus-like adnexal mass
  • splenic gonadal fusion
  • pregnancy luteoma
  • hyperreactio luteinalis
  • large solitary luteinized follicle cyst of pregnancy and puerperium
  • granulosa cell proliferations of pregnancy
  • hilus Leydig cell proliferation of pregancy
  • ectopic decidua
  • ovarian pregnancy
  • ovarian endometriosis (ovarian endometriotic cyst )
  • ovarian granulomas
    • ovarian foreign body granulomas
    • ovarian palisading granulomas
    • ovarian granulomas secondary to systemic diseases
  • mesothelial proliferations
  • surface epithelial-stromal proliferation
  • autoimmune oophoritis
  • ovarian torsion
  • ovarian infarction
  • ovarian changes secondary to metabolic diseases
  • mucicarminophilic histiocytosis

See also

- ovarian carcinomas
- ovarian carcinogenesis / ovarian tumorigenesis

References

- Shih IeM, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol. 2004 May;164(5):1511-8. PMID: 15111296

Portfolio

  • Ovarian mature teratoma (dermoid cyst)
  • Ovarian mature teratoma (dermoid cyst)
  • Ovarian thecoma
  • Ovarian thecoma
  • Ovarian fibrothecoma
  • Ovarian fibrothecoma
  • Ovarian fibrothecoma
  • Ovarian carcinoma
  • Ovarian carcinoma
  • Ovarian carcinoma