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ovarian tumors

Friday 25 July 2003

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Classification (WHO)

I - Ovarian epithelial tumors (Surface epithelial-stromal tumors)

  • ovarian serous tumors
    • benign ovarian serous tumors
    • proliferating ovarian serous tumors - borderline ovarian serous tumors
    • ovarian serous carcinomas
  • ovarian mucinous tumors
    • pseudomyxoma peritonei
    • benign ovarian mucinous tumors
    • proliferating ovarian mucinous tumors - borderline mucinous tumors
    • mucinous ovarian carcinomas
  • Endometrioid tumors:
    • Benign (cystadenoma)
    • Borderline tumors (endometrioid borderline tumor)
    • Malignant (endometrioid adenocarcinoma)
  • Clear cell tumors:
    • Benign
    • Borderline tumors
    • Malignant (clear cell adenocarcinoma)
  • Transitional cell tumors
    • Brenner tumor
    • Brenner tumor of borderline malignancy
    • Malignant Brenner tumor
    • Transitional cell carcinoma (non-Brenner type)
  • Squamous cell tumors
  • Epithelial-stromal tumors (Mixed epithelial tumors)
    • Adenosarcoma
    • Carcinosarcoma (formerly "mixed Mullerian tumors")
  • Undifferentiated / unclassified epithelial tumors
    • Adenocarcinoma (NOS)
    • Undifferentiated carcinoma

II - Ovarian sex cord-stromal tumors

  • Granulosa-stromal cell tumors
    • thecoma-fibroma group
      • ovarian fibroma
      • thecoma
      • fibrothecoma
    • Granulosa tumors
      • Adult type
      • Juvenile type
  • Sertoli-stromal cell tumors
    • Sertoli-Leydig cell tumor (Androblastoma)
    • Sertoli cell tumor
    • Stromal-Leydig cell tumor
  • Sex cord-stromal tumors of mixed or unclassified cell types
    • Sex cord tumor with annular tubules
    • Gynandroblastoma
    • Sex cord-stromal tumor, unclassified, NOS
  • Steroid cell tumors
    • Stromal luteoma
    • Leydig cell tumor
      • Leydig cell tumor, Hilus cell tumor type
      • Leydig cell tumor, non-hilar type
      • Leydig cell tumor, NOS
    • Steroid (lipid) cell tumors NOS
      • Well differentiated
      • Malignant

III - Ovarian germ cell tumors

  • Teratoma:
    • Immature
    • Mature
      • Solid
      • Cystic (dermoid cyst)
      • Monodermal (e.g., struma ovarii, carcinoid)
  • Dysgerminoma
  • Yolk sac tumor (endodermal sinus tumor)
  • Mixed germ cell tumors

IV. Miscellaneous tumors

  • Metastasis
    • Colonic, appendiceal
    • Gastric
    • Breast

Macroscopical appearance

- ovarian cystic tumors
- ovarian surface epithelial tumors

Microscopical appearance

- ovarian tumors with prominent spindle cells

Differential diagnosis

- ovarian tumor-like lesions

  • follicle cyst
  • corpus luteum cyst
  • ovarian remnant syndrome
  • polycystic ovarian disease (PCOD)
  • stroma hyperthecosis
  • ovarian stromal hyperplasia
  • ovarian massive edema
  • ovarian fibromatosis
  • hilus Leydig cell hyperplasia
  • ovarian simple cyst
  • ovarian idiopathic calcification
  • uterus-like adnexal mass
  • splenic gonadal fusion
  • pregnancy luteoma
  • hyperreactio luteinalis
  • large solitary luteinized follicle cyst of pregnancy and puerperium
  • granulosa cell proliferations of pregnancy
  • hilus Leydig cell proliferation of pregancy
  • ectopic decidua
  • ovarian pregnancy
  • ovarian endometriosis (ovarian endometriotic cyst)
  • ovarian granulomas
    • ovarian foreign body granulomas
    • ovarian palisading granulomas
    • ovarian granulomas secondary to systemic diseases
  • ovarian infections
    • ovarian bacterial infections
      • ovarian actinomycosis
      • ovarian tuberculosis
      • ovarian malacoplakia
    • ovarian fungal infections
    • ovarian parasitic infections
  • mesothelial proliferations
  • surface epithelial-stromal proliferation
  • autoimmune oophoritis
  • ovarian torsion
  • ovarian infarction
  • ovarian changes secondary to metabolic diseases
  • mucicarminophilic histiocytosis

See also

- ovarian carcinomas
- ovarian tumorigenesis

References

- Shih IeM, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol. 2004 May;164(5):1511-8. PMID: #15111296#

Portfolio

  • Ovarian mature teratoma (dermoid cyst)
  • Ovarian mature teratoma (dermoid cyst)
  • Ovarian thecoma
  • Ovarian thecoma
  • Ovarian fibrothecoma
  • Ovarian fibrothecoma
  • Ovarian fibrothecoma
  • Ovarian carcinoma
  • Ovarian carcinoma
  • Ovarian carcinoma