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15q25-26 amplification

15q25-26 amplicon

Friday 7 October 2005

Target genes:

- IGF1R

Tumors

- IGF1R overexpression by 15q25-26 amplicon amplification in tumors

- increased copy number at chromosome 15q26.3

See also

- 15q gain

References

- Natrajan R, Reis-Filho JS, Little SE, Messahel B, Brundler MA, Dome JS, Grundy PE, Vujanic GM, Pritchard-Jones K, Jones C. Blastemal expression of type I insulin-like growth factor receptor in Wilms’ tumors is driven by increased copy number and correlates with relapse. Cancer Res. 2006 Dec 1;66(23):11148-55. PMID: 17145858