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anaplastic astrocytoma

Friday 7 October 2005

Anaplastic astrocytoma (AA, WHO grade III) is, second to Glioblastoma, the most common and most malignant type of adult CNS tumour.

Cytogenetics

In anaplastic astrocytomas, chromosome gains or losses are frequent:
- trisomy 7 (the most frequent)
- loss of chromosome 10
- loss of chromosome 22
- loss of 9p,
- loss of 13q.

Other abnormalities, less frequently described are: gains of chromosomes 1q, 11q, 19, 20, and Xq.

Molecular biology

- loss of both wild-type copies of genes in the RB1 pathway (15970925)

- amplification and overexpression of CDK4

References

- Backlund LM, Nilsson BR, Liu L, Ichimura K, Collins VP. Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. Br J Cancer. 2005 Jul 11;93(1):124-30. PMID: 15970925