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FOXO3A

MIM.602681 6q21

Friday 7 October 2005

Pathology

- t(6;11)(q21;q23) translocation (6q21 and 11q23) in secondary acute myeloblastic leukemia

Nota bene: Two other forkhead genes have been shown to be involved in distinct chromosomal translocations associated with malignancies:
- the AFX gene (MIM.300033), which is fused to the MLL gene in 1 type of acute lymphoblastic leukemia (ALL)
- the FOXOA1 (MIM.136533) gene, which is fused to the PAX3 (MIM.606597) or PAX7 (MIM.167410) gene in alveolar rhabdomyosarcoma.

See also

- FOXOs

References

- Hillion, J.; Le Coniat, M.; Jonveaux, P.; Berger, R.; Bernard, O. A. : AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood 90: 3714-3719, 1997. PubMed ID : #9345057#

Portfolio

  • FOXO3A and DNA damage