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progressive multifocal leukoencephalopathy

Thursday 6 October 2005


Definition: The only human disease caused by an infection with the human JC polyomavirus (JCV) is progressive multifocal leukoencephalopathy (PML) characterized by a lytic infection of oligodendrocytes with consecutive demyelination.


- Bizarre nuclei of progressive multifocal leukoencephalopathy. JC virus ISH.


- HIV infection
- genetic immunodeficiencies
- JC virus infection

See also

- papovavirus
- polyomaviruses

  • JC polyomavirus
  • BK polyomavirus


- Koralnik IJ. New insights into progressive multifocal leukoencephalopathy. Curr Opin Neurol. 2004 Jun;17(3):365-70. PMID: 15167073

- Hair LS, Nuovo G, Powers JM, Sisti MB, Britton CB, Miller JR. Progressive multifocal leukoencephalopathy in patients with human immunodeficiency virus. Hum Pathol. 1992 Jun;23(6):663-7. PMID: 1592389