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NUP98

MIM.601021

Tuesday 4 October 2005

Nucleoporin-98

Definition: Nucleoporin-98 is a 98 kDa component of the nuclear pore complex implicated in nucleo-cytoplasmic transport.

Pathology

- fusion genes formation by translocations

  • NUP98-HOXD13 fusion gene in acute myeloid leukemia
  • NUP98-PRRX2 fusion gene in acute myeloid leukemia in acute myelomonocytic leukemia (M4 ANLL) by t(9;11)(q34;p15) (9q34 and 11p15)
  • NUP98-NSD1 fusion gene
  • NUP98-NSD3 fusion gene
  • NUP98-PMX1 fusion gene
  • NUP98-HOXA9 fusion gene
  • NUP98-TOP1 fusion gene
  • NUP98-DDX10 fusion gene
  • NUP98-HOXD11 fusion gene
  • NUP98-HOXC13 fusion gene
  • NUP98-ADD3 fusion gene
  • NUP98-PRRX2 fuison gene in acute myelomonocytic leukemia (M4 ANLL) by t(9;11)(q34;p15) (9q34.1 and 11p15)
  • NUP98-JARID1A (12p13) by t(4;11)(q13;p15) in leukemias (16419055)

References

- van Zutven LJ, Onen E, Velthuizen SC, van Drunen E, von Bergh AR, van den Heuvel-Eibrink MM, Veronese A, Mecucci C, Negrini M, de Greef GE, Beverloo HB. Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer. 2006 May;45(5):437-46. PMID: 16419055

- A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Gervais C, Mauvieux L, Perrusson N, Helias C, Struski S, Leymarie V, Lioure B, Lessard M. Leukemia 2005; 19: 145-148. PMID: 15496970

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