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Eker rat

Tuesday 27 September 2005

The Eker rat is one of the best characterized models of tuberous sclerosis complex (TSC) and has been used extensively for study of the function of the TSC2 tumor suppressor gene.

Along with TSC1, these two genes behave as expected for tumor suppressor genes with evidence for loss of heterozygosity in tumors and suppression of growth when expressed in proliferating cells.

References

- Cook JD, Walker CL. The Eker rat: establishing a genetic paradigm linking renal cell carcinoma and uterine leiomyoma. Curr Mol Med. 2004 Dec;4(8):813-24. PMID: 15579028

- Hino O. Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model. Curr Mol Med. 2004 Dec;4(8):807-11. PMID: 15579027

- Yeung RS. Lessons from the Eker rat model: from cage to bedside. Curr Mol Med. 2004 Dec;4(8):799-806. PMID: 15579026

- Yeung RS. Multiple roles of the tuberous sclerosis complex genes. Genes Chromosomes Cancer. 2003 Dec;38(4):368-75. PMID: 14566857

- Walker CL, Hunter D, Everitt JI. Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer. 2003 Dec;38(4):349-56. PMID: 14566855