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KIT

MIM.164920

Saturday 19 July 2003

See also CD117 IHCDB

Expression in cells

- c-KIT positive spermatogonia

Expression in tumors (Exemples)

- chromophobe renal cell carcinoma (100%)
- renal oncocytoma (100%)

Pathology

- KIT activating mutations in

  • gastrointestinal stromal tumor (GIST)
  • mastocytosis
  • testicular germ-cell tumors (TGCT)

Use in diagnosis

- Differential diagnosis between chromophobe renal cell carcinoma and the granular variant of clear cell renal cell carcinoma (#15832088#)

- KIT is an independent prognostic marker for pancreatic endocrine tumors. (#19574886#)

References

Expression in normal cells

- Immunohistochemical expression analysis of Cx43, Cx26, c-KIT and PlAP in contralateral testis biopsies of patients with non-seminomatous testicular germ cell tumor. Steiner M, Weipoltshammer K, Viehberger G, Meixner EM, Lunglmayr G, Schöfer C. Histochem Cell Biol. 2011 Jan;135(1):73-81. PMID: #21161545#

Expression in tumors

- KIT is an Independent Prognostic Marker for Pancreatic Endocrine Tumors: A Finding Derived From Analysis of Islet Cell Differentiation Markers. Zhang L, Smyrk TC, Oliveira AM, Lohse CM, Zhang S, Johnson MR, Lloyd RV. Am J Surg Pathol. 2009 Jul 1. PMID: #19574886#

- Wang HY, Mills SE. KIT and RCC Are Useful in Distinguishing Chromophobe Renal Cell Carcinoma From the Granular Variant of Clear Cell Renal Cell Carcinoma. Am J Surg Pathol. 2005 May;29(5):640-646. PMID: #15832088#