Home > A. Molecular pathology > KIT



Saturday 19 July 2003

See also CD117 IHCDB

Expression in cells

- c-KIT positive spermatogonia

Expression in tumors (Exemples)

- chromophobe renal cell carcinoma (100%)
- renal oncocytoma (100%)


- KIT activating mutations in

Use in diagnosis

- Differential diagnosis between chromophobe renal cell carcinoma and the granular variant of clear cell renal cell carcinoma (15832088)

- KIT is an independent prognostic marker for pancreatic endocrine tumors. (19574886)


Expression in normal cells

- Immunohistochemical expression analysis of Cx43, Cx26, c-KIT and PlAP in contralateral testis biopsies of patients with non-seminomatous testicular germ cell tumor. Steiner M, Weipoltshammer K, Viehberger G, Meixner EM, Lunglmayr G, Schöfer C. Histochem Cell Biol. 2011 Jan;135(1):73-81. PMID: 21161545

Expression in tumors

- KIT is an Independent Prognostic Marker for Pancreatic Endocrine Tumors: A Finding Derived From Analysis of Islet Cell Differentiation Markers. Zhang L, Smyrk TC, Oliveira AM, Lohse CM, Zhang S, Johnson MR, Lloyd RV. Am J Surg Pathol. 2009 Jul 1. PMID: 19574886

- Wang HY, Mills SE. KIT and RCC Are Useful in Distinguishing Chromophobe Renal Cell Carcinoma From the Granular Variant of Clear Cell Renal Cell Carcinoma. Am J Surg Pathol. 2005 May;29(5):640-646. PMID: 15832088