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MIM.603598 3q26

Tuesday 30 August 2005

TNF-related apoptosis inducing ligand (TRAIL/Apo-2L) is a typical member of the TNF ligand family that induces apoptosis through activating the death receptors.

Tumor necrosis factor (TNF) family cytokines function as prominent mediators of immune regulation and the inflammatory response.

Most TNF family cytokines are expressed as type II transmembrane proteins, with homology confined to approximately 150 C-terminal residues. The TNF ligands interact with a parallel family of receptors (TNFSFs).

See also

- Apoptosis


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- Shi J, Zheng D, Man K, Fan ST, Xu R. TRAIL: a potential agent for cancer therapy. Curr Mol Med. 2003 Dec;3(8):727-36. PMID: 14682494