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protein kinase inhibitors

Monday 29 August 2005

protein-kinase inhibitor ; PKIs

WKPD

Definition: A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that add a phosphate (PO4) group to a protein, and can modulate its function.

Protein-kinase inhibitors are generally small molecules that show competitive inhibition with respect to ATP.

Examples

- tyrosine kinase inhibitors (TKIs )

References

- Bogoyevitch MA. Therapeutic promise of JNK ATP-noncompetitive inhibitors. Trends Mol Med. 2005 May;11(5):232-9. PMID: 15882611