protein kinase inhibitors
Monday 29 August 2005
protein-kinase inhibitor ; PKIs
Definition: A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that add a phosphate (PO4) group to a protein, and can modulate its function.
Protein-kinase inhibitors are generally small molecules that show competitive inhibition with respect to ATP.
tyrosine kinase inhibitors (TKIs )
Bogoyevitch MA. Therapeutic promise of JNK ATP-noncompetitive inhibitors. Trends Mol Med. 2005 May;11(5):232-9. PMID: 15882611