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Monday 29 August 2005

Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH(2)-terminal kinase (JNK) pathway exemplifies one subgroup of the mitogen-activated protein (MAP) kinases, which, besides having established functions in stress response, also contribute to development by an unknown mechanism.

JNK-bound promoters are enriched with binding motifs for the transcription factor NF-Y but not for AP-1.

NF-Y occupies these predicted sites, and overexpression of dominant-negative NF-YA reduces the JNK presence on chromatin.

MAP kinase binding and function on chromatin is a novel class of target genes during stem cell differentiation.


- Bogoyevitch MA. Therapeutic promise of JNK ATP-noncompetitive inhibitors. Trends Mol Med. 2005 May;11(5):232-9. PMID: 15882611


- A chromatin-modifying function of JNK during stem cell differentiation. Tiwari VK, Stadler MB, Wirbelauer C, Paro R, Schübeler D, Beisel C. Nat Genet. 2011 Dec 18;44(1):94-100. PMID: 22179133