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splenic stem cells

Monday 29 August 2005

The spleen of adult mice holds a reservoir of stem cells that can rapidly and robustly differentiate into functional cells of diverse lineages.

Splenic stem cells express Hox11, a key embryonic transcription factor that regulates organogenesis.

The presence of multi-lineage stem cells in the spleen might represent lifelong persistence of cells from a primitive embryonic region called the aorta-gonad-mesonephros.

References

- Kodama S, Davis M, Faustman DL. Regenerative medicine: a radical reappraisal of the spleen. Trends Mol Med. 2005 Jun;11(6):271-6. PMID: #15949768#