splenic stem cells
Monday 29 August 2005
The spleen of adult mice holds a reservoir of stem cells that can rapidly and robustly differentiate into functional cells of diverse lineages.
Splenic stem cells express Hox11, a key embryonic transcription factor that regulates organogenesis.
The presence of multi-lineage stem cells in the spleen might represent lifelong persistence of cells from a primitive embryonic region called the aorta-gonad-mesonephros.