Home > A. Molecular pathology > ASPM
ASPM
MIM.605481 1q31
Monday 20 June 2005
The ASPM gene is the human ortholog of the Drosophila melanogaster ’abnormal spindle’ gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. The mouse gene Aspm is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis.
Pathology
primary autosomal recessive microcephaly (MIM.608716)