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11q LOH

Monday 20 June 2005

Tumors

- Wilms tumor (17099873, 16518847)
- pulmonary carcinomas
- colorectal adenocarcinomas (colorectal cancer)
- mammary carcinomas (breast cancer) ( 60%)
- cervical squamous cell carcinoma
- head and neck squamous cell carcinoma (HNSCC) ( 60%)
- ovarian carcinomas ( 60%)

Localization

- 11q22-q24 LOH

  • pulmonary carcinomas
  • colonic carcinomas
  • mammary carcinomas
  • cervical carcinomas
  • head and neck carcinomas (17492757)

See also

- 11q loss (CGH)
- 11q deletion (Cytogenetics)
- Oncobase

References

- Parikh RA, White JS, Huang X, Schoppy DW, Baysal BE, Baskaran R, Bakkenist CJ, Saunders WS, Hsu LC, Romkes M, Gollin SM. Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma. Genes Chromosomes Cancer. 2007 May 10;46(8):761-775 PMID: 17492757

- Wittmann S, Zirn B, Alkassar M, Ambros P, Graf N, Gessler M. Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis. Genes Chromosomes Cancer. 2007 Feb;46(2):163-70. PMID: 17099873

- Watanabe N, Nakadate H, Haruta M, Sugawara W, Sasaki F, Tsunematsu Y, Kikuta A, Fukuzawa M, Okita H, Hata J, Soejima H, Kaneko Y. Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. Genes Chromosomes Cancer. 2006 Jun;45(6):592-601. PMID: 16518847