Wednesday 25 May 2005
CD34 is a monomeric cell surface sialomucin with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.
At least three endothelial cell ligands can bind L-selectin:
glycan-bearing cell adhesion molecule-1 (GlyCAM-1), a secreted proteoglycan found on HEVs of lymph node
mucosal addressin cell adhesion molecule-1 (MadCAM-1), expressed on endothelial cells in gut-associated lymphoid tissues
CD34, a proteoglycan on endothelial cells (and bone marrow cells).
The protein backbones of all these ligands are modified by specific carbohydrates, which are the molecules actually recognized by the selectins (SELs).
Expression in normal cells
human hematopoietic progenitor cells
Expression in tumors
solitary fibrous tumors
dermatofibrosarcoma protuberans and giant cell fibroblastoma
+/- acute leukemias
nodular hairy dendritic hamartoma of the newborn
smooth muscle hamartoma
CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. Westerhoff M, Tretiakova M, Hovan L, Miller J, Noffsinger A, Hart J. Am J Surg Pathol. 2010 Apr;34(4):494-501. PMID: #20351488#