Saturday 23 April 2005
Corneocytes are anucleated cells derived from keratinocytes during the late stages of terminal differentiation of cornified squamous epithelia such as the epidermis.
Corneodesmosomes are intercellular structures that are involved in desquamation, the shedding of superficial corneocytes from the skin surface.
Corneocyte desquamation at the skin surface is a complex biologic event which is normally regulated for providing an inconspicuous shedding of single corneocytes. When altered, the process gives rise to xerotic and ichthyotic conditions.
There is a complex relationship between epidermal cell production, maturation and desquamative loss. Corneocyte hydration, stratum corneum barrier function and enzymatic corneodesmolysis are involved in a dynamic interrelationship.
hypotrichosis simplex of the scalp (MIM.146520)
corneodesmosin (CDSN) (rotein of corneodesmosomes)
Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40. PMID: #15803139#
Pierard GE, Goffin V, Hermanns-Le T, Pierard-Franchimont C. Corneocyte desquamation. Int J Mol Med. 2000 Aug;6(2):217-21. PMID: #10891569#