Saturday 23 April 2005
Corneocyte desquamation at the skin surface is a complex biologic event which is normally regulated for providing an inconspicuous shedding of single corneocytes. When altered, the process gives rise to xerotic and ichthyotic conditions.
There is a complex relationship between epidermal cell production, maturation and desquamative loss. Corneocyte hydration, stratum corneum barrier function and enzymatic corneodesmolysis are involved in a dynamic interrelationship.
hypotrichosis simplex of the scalp (MIM.146520)
corneodesmosin (CDSN) (rotein of corneodesmosomes)