Saturday 23 April 2005
Corneocyte desquamation at the skin surface is a complex biologic event which is normally regulated for providing an inconspicuous shedding of single corneocytes. When altered, the process gives rise to xerotic and ichthyotic conditions.
There is a complex relationship between epidermal cell production, maturation and desquamative loss. Corneocyte hydration, stratum corneum barrier function and enzymatic corneodesmolysis are involved in a dynamic interrelationship.
hypotrichosis simplex of the scalp (MIM.146520)
corneodesmosin (CDSN) (rotein of corneodesmosomes)
Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40. PMID: 15803139
Pierard GE, Goffin V, Hermanns-Le T, Pierard-Franchimont C. Corneocyte desquamation. Int J Mol Med. 2000 Aug;6(2):217-21. PMID: 10891569