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Friday 15 April 2005


Digital cases (Examples)

- HPC:296 : Colonic MALT lymphoma
- HPC:302 : Mediastinal-pulmonary diffuse large B-cell lymphoma (DLBCL), EBV-associated
- HPC:305 : diffuse large B-cell lymphoma of the tonsil (DLBCL of the tonsil)


- B-cell lymphomas
- T-cell lymphomas

WHO classification of lymphomas (2008)

The mature B-cell neoplasms (WHO 2008)

- chronic lymphocytic leukemia/small lymphocytic lymphoma
- B-cell prolymphocytic leukemia
- splenic marginal zone B-cell lymphoma (SMZBCL)
- hairy cell leukemia
- splenic lymphoma/leukemia, unclassifiable

  • splenic diffuse red pulp small B-cell lymphoma
  • hairy cell leukemia variant

- lymphoplasmacytic lymphoma

  • Waldenstrom macroglobulinemia

- heavy chain diseases

  • alpha heavy chain disease
  • gammaheavy chain disease
  • mu heavy chain disease

- plasma cell myeloma
- solitary plasmocytoma of the bone
- extraosseous plasmocytoma
- extranodal marginal zone B-cell lymphoma (extranodal MZBCL) (MALT lymphoma)
- nodal marginal zone B-cell lymphoma (nodal MZBCL)
- follicular lymphoma (follicular B-cell lymphoma, follicle centre cell lymphoma)

  • pediatric type follicular lymphoma

- primary cutaneous follicle centre cell lymphoma
- mantle cell lymphoma
- diffuse large B-cell lymphomas (DLBCL), not othrwise specified (NOS)

  • T cell/histiocyte rich large B-cell lymphoma
  • DLBCL with chronic inflammation
  • EBV+ DLBCL of the elderly

- lymphomatoid granulomatosis
- primary mediastinal (thymic) large B-cell lymphoma
- intravascular large B-cell lymphoma
- primary cutaneous DLBCL, leg type
- ALK+ large B-cell lymphoma
- plasmablastic lymphoma
- primary effusion lymphoma
- large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
- Burkitt lymphoma
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Hodgkin lymphoma

- nodular lymphocyte-predominant Hodgkin lymphoma
- classical Hodgkin lymphoma

  • nodular sclerosis classical Hodgkin lymphoma
  • lymphocyte-rich classical Hodgkin lymphoma
  • mixed cellularity classical Hodgkin lymphoma
  • lymphocyte-depleted classical Hodgkin lymphoma

The mature T-cell and NK-cell neoplasms (WHO 2008)

Diagnosis of lymphomas

- B-cell lymphomas

- T-cell lymphomas


- Staudt LM. Molecular diagnosis of the hematologic cancers.
N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484

- K├╝ppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: 15803153

- O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: 17934490