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Budd-Chiari syndrome

Friday 15 April 2005

The etiology of the Budd-Chiari syndrome is a spectrum of disease states, including anatomic abnormalities and hypercoagulable disorders, resulting in hepatic venous outflow occlusion.

Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain, and abdominal ascites. This article outlines the approach to clinical diagnosis and supportive medical therapy in patients who have BCS and reviews the clinical data supporting surgical shunting and liver transplantation as viable treatment options in this patient population.

Etiology

- anatomic anomalies

- sus-hepatic venous thrombosis

  • hypercoagulable state (hypercoagulable disorders)
    • oral contraceptive usage
    • antithrombin III deficiency

- pyogenic liver abscess (16201117)

- intrahepatic narrowing of the inferior vena cava (4952469)

See also

- acute Budd-Chiari syndrome

References

- Menon KV, Shah V, Kamath PS. The Budd-Chiari syndrome. N Engl J Med. 2004 Feb 5;350(6):578-85. PMID: 14762185