Thursday 7 April 2005
Definition: Bioinformatics is defined as the large-scale storage, retrieval and assessment of data from biological studies. This field draws on high-performance computing, software and information technology.
Genomic information is too voluminous for even a large team of researchers to remember or analyze, so the information is placed in complex databases in which the gene and protein structures and functions can be easily accessed, cross-referenced or queried.
Bioinformatics deals with algorithms, databases and information systems, web technologies, artificial intelligence and soft computing, information and computation theory, software engineering, data mining, image processing, modeling and simulation, signal processing, discrete mathematics, control and system theory, circuit theory, and statistics, for generating new knowledge of biology and medicine, and improving and discovering new models of computation (e.g. DNA computing, neural computing, evolutionary computing, immuno-computing, swarm-computing, cellular-computing).
Java, XML, Perl, C, C++, Python, R, SQL and MatLab are the some of the more prominent software technologies used in this field.
sequence analysis (sequence alignment, sequence database)
computational evolutionary biology
biological litterature analysis (text mining)
analysis of gene expression
analysis of gene regulation
analysis of protein expression
analysis of mutations in cancer
modeling biological systems (computational systems biology)
high-throughput image analysis
in silico biology
metabolic network modelling
molecular design software
- protein structure prediction
- molecualr interaction prediction
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Hanauer DA, Rhodes DR, Sinha-Kumar C, Chinnaiyan AM. Bioinformatics approaches in the study of cancer. Curr Mol Med. 2007 Feb;7(1):133-41. PMID: 17311538
Hu P, Bader G, Wigle DA, Emili A. Computational prediction of cancer-gene function. Nat Rev Cancer. 2007 Jan;7(1):23-34. PMID: 17167517
Kanehisa M, Bork P. Bioinformatics in the post-sequence era. Nat Genet. 2003 Mar;33 Suppl:305-10. PMID: 12610540